Publications

SMAC-Technology:

Beerli, R. R., Hell, T., Merkel, A., and Grawunder, U. (2015) Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency. PLoS ONE 10, e0131177.
Published: July 2015

Highly potent PNU payload:

Stefan, N., Gébleux, R., Waldmeier, L., Hell, T., Escher, M., Wolter., F. I., Grawunder, U., & Beerli, R. R. (2017) Highly potent, anthracycline-based antibody drug conjugates generated by enzymatic, site-specific conjugation. Mol Cancer Ther 16, 879-892.
Published: May 2017

IO function of NBE's PNU payload:

D’Amico, L., Menzel, U., Prummer, M., Buchi, M., Müller, P., Kashyap, A., Haessler, U., Yermanos, A., Gébleux, R., Briendl, M., Hell, M., Wolter, F. I., Beerli, R. R., Truxova, I Radek, S., Tatjana, V., Grawunder, U., Reddy, S., & Zippelius, A. (2019) A novel anti-HER2 anthracycline-based antibody-drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer. J. Imm. Ther. Cancer 7: 16
Published: January 2019

Transpo-Mab antibody discovery platform:

Hellmann, I., Waldmeier, L., Bannwarth-Escher, M., Maslova, K., Wolter, F. I., Grawunder, U. & Beerli, R. R. (2008) Novel antibody drug conjugates targeting tumor-associated receptor tyrosine kinase ROR2 by functional screening of fully human antibody libraries using Transpo-mAb display on progenitor B cells. (2018) Front. Immunol. 9, 2490.
Published: November 2018

Waldmeier, L., Hellmann, I., Gutknecht, C. K., Wolter, F. I., Cook, S. K., Reddy, S. T., Grawunder, U. & Beerli, R. R. (2016) Transpo-mAb Display: transposition-mediated B cell display and functional screening of full-length IgG antibody libraries. mAbs 8, 726-740.
Published: April 2016

ROR1 antibody discovery:

Peng, H., Nerreter, T., Chang, J., Qi, J., Li, X., Karunadharma, P., Martinez, G., Fallahi, M., Soden, J., Freeth, J., Beerli, R. R., Grawunder, U., Hudecek, M., & Rader, C. (2017) Mining Naïve Rabbit Antibody Repertoires by Phage Display for Monoclonal Antibodies of Therapeutic Utility. J. Mol. Biol. 429, 2954–2973.
Published: September 2017